Sevoflurane CAS 28523-86-6

Description

1. Pharmaceutical Overview
Sevoflurane (CAS 28523-86-6), marketed under the brand name Ultane among others, represents the gold standard in modern inhalation anesthesia. This fluorinated methyl isopropyl ether is among the most widely used volatile anesthetics globally due to its favorable pharmacokinetic profile and excellent safety record.

For medical professionals researching what is sevoflurane, it is a non-flammable, rapid-acting inhalational anesthetic with low blood-gas solubility that facilitates precise control over anesthetic depth. As a premier inhaled anesthetic, sevoflurane gas offers superior controllability compared to older agents like isoflurane, making it indispensable in both human and veterinary sevoflurane practice.

2. Elite Technical Specifications

• Chemical Name: 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
• Synonyms: Ultane, Sevoflurane
• CAS Number: 28523-86-6
• Molecular Formula: C₄H₃F₇O
• Molecular Weight: 200.06 g/mol
• Appearance: Clear, colorless liquid
• Purity: ≥99.9% (USP Grade, GC-verified)
• Vapor Pressure: 157 mmHg at 20°C (sevoflurane vapor pressure)
• Blood-Gas Partition Coefficient: 0.65 (20°C)
• MAC Value: 2.05% in adults (sevoflurane MAC)
• Storage: Store in sealed containers at controlled room temperature

3. Authorized Applications & Uses
Our premium Sevoflurane serves critical roles across medical specialties:

1. Human Medical Anesthesia

• General Anesthesia: Primary agent for induction and maintenance of inhalational anesthesia
• Pediatric Anesthesia: Preferred choice due to smooth induction characteristics
• Outpatient Surgery: Ideal for rapid emergence and recovery profiles
• Cardiac Anesthesia: Used in cardiovascular procedures requiring hemodynamic stability

2. Veterinary Anesthesia

• Small Animal Practice: Sevoflurane veterinary use in dogs and cats
• Exotic Animal Anesthesia: Preferred for avian and reptilian species
• Large Animal Applications: Used in equine and bovine anesthesia

3. Research Applications

• Neuroscience Research: Studies of anesthetic mechanisms and neuroprotection
• Pharmacological Studies: Investigation of sevoflurane mechanism of action
• Comparative Research: Sevoflurane vs isoflurane efficacy and safety studies

4. Clinical & Pharmacological Profile
Understanding Sevoflurane’s Medical Applications:

Mechanism of Action:

• Enhances GABAergic inhibition in central nervous system
• Potentiates glycine receptor activity
• Inhibits neuronal nicotinic acetylcholine receptors
• Sevoflurane MOA involves multiple molecular targets

Dosage & Administration:

• Sevoflurane dosage typically 0.5–8% inspired concentration
• Route of administration: Inhalation via precision vaporizer
• MAC values vary with age: neonates 3.3%, infants 3.2%, adults 2.0%, elderly 1.5%

Comparative Pharmacology:

• Sevoflurane vs isoflurane: Lower blood solubility (0.65 vs 1.4) enables faster induction/recovery
• Isoflurane vs sevoflurane veterinary: Sevoflurane preferred for faster recovery in animals
• Isoflurane and sevoflurane both provide stable hemodynamic profiles

Pregnancy Considerations:

• Gases during pregnancy require careful risk-benefit analysis
• Sevoflurane in pregnancy generally considered safe when medically necessary

5. Critical Safety & Handling Information
WARNING: SEVOFLURANE IS A POTENT GENERAL ANESTHETIC WITH SERIOUS RESPIRATORY AND CARDIAC EFFECTS. It must be administered only by trained anesthesia professionals using appropriate equipment.

Safety Data:

• Sevoflurane side effects include nausea, vomiting, and respiratory depression
• Contraindications: Malignant hyperthermia susceptibility, known hypersensitivity
• Pregnancy Category: B (animal studies show no risk, human data limited)
• Not flammable under normal conditions (is sevoflurane flammable – No)

Handling Protocols:

• Use approved anesthesia vaporizers only
• Maintain adequate ventilation in procedure areas
• Follow occupational exposure guidelines
• Store in original containers protected from light

6. Order Now – For Medical Facilities Only
Secure Your Pharmaceutical-Grade Anesthetic
Ensure the highest standard of patient care with our certified Sevoflurane.

USP PHARMACEUTICAL GRADE:

• Batch-specific Certificate of Analysis
• GC purity verification ≥99.9%
• Full USP compliance documentation
• cGMP manufacturing standards

Available Quantities:

• 250 mL (Ideal for surgical facilities)
• 500 mL (Hospital pharmacy applications)
• 1000 mL (Large medical center use)
• Custom Quantities – (Contact for bulk pricing)

Every Order Includes:

• Certificate of Analysis (CoA) with full USP testing data
• Sevoflurane SDS (Safety Data Sheet)
• USP Compliance Documentation
• Regulatory Support Documents
• Secure, Pharmaceutical-Grade Packaging