Mebroqualone

Description

1. Comprehensive Scientific Overview
Mebroqualone is a synthetic sedative-hypnotic compound belonging to the quinazolinone class, structurally and pharmacologically related to older medications such as methaqualone and mecloqualone. As a research chemical, it is of significant interest to neuroscientists and pharmacologists studying the modulation of the GABAergic system. Unlike its more famous predecessors, Mebroqualone is noted in limited pre-clinical literature for its distinct pharmacological profile, potentially offering a unique tool for investigating GABA-A receptor subtypes and their role in sedation, anxiety, and seizure thresholds. Our product is synthesized to the highest standards of purity, providing researchers with a reliable and consistent compound for in-vitro and animal model studies.

2. Advanced Chemical Specifications & Properties

• Chemical Name: 3-(2-Bromophenyl)-2-methylquinazolin-4(3H)-one
• Synonyms: MBQ, CCNU
• CAS Number: 56205-74-8
• Molecular Formula: C₁₅H₁₁BrN₂O
• Molecular Weight: 315.17 g/mol
• Appearance: Fine, crystalline white to off-white powder
• Purity: ≥98% (HPLC-verified with full chromatographic report)
• Solubility: Soluble in DMSO, ethanol, and acetone; sparingly soluble in water
• Storage: Store at 2–8°C in a sealed, light-resistant container to ensure long-term stability
• Stability: 24 months when stored under recommended conditions

3. Cutting-Edge Research Applications
Our premium Mebroqualone for sale is intended for controlled, ethical research in qualified laboratory settings. Its primary applications include:

1. Neuropharmacological Research

• GABA-A Receptor Studies: Investigation of binding affinity and efficacy at specific benzodiazepine-binding sites on the GABA-A receptor complex
• Subtype Selectivity: Research into potential selectivity for receptor subtypes containing specific alpha and gamma subunits, which could elucidate mechanisms of sedation and anxiolysis
• Comparative Pharmacology: Studies comparing its effects to other quinazolinone derivatives (e.g., methaqualone) and classical benzodiazepines

2. Behavioral Pharmacology

• Analysis of sedative, hypnotic, and muscle-relaxant properties in validated animal models
• Investigation of its effects on motor coordination, anxiety-like behavior, and seizure susceptibility
• Studies on the development of tolerance and dependence

3. Metabolic & Toxicological Research

• Identification and characterization of its major metabolic pathways and metabolites
• In-vitro assessment of potential hepatotoxicity and cellular toxicity
• Pharmacokinetic studies including absorption, distribution, and elimination

4. CRITICAL SAFETY & HANDLING PROTOCOL
WARNING: Mebroqualone is a potent psychoactive substance with central nervous system depressant effects. It poses significant risks, including profound sedation, respiratory depression, dependence, and potential toxicity. It is strictly NOT intended for human consumption. This product is for forensic and scientific research use only.

Mandatory Safety Protocols for Researchers:

• Environment: All handling should be conducted in a well-ventilated area or a certified chemical fume hood
• Personal Protective Equipment (PPE): Mandatory use of nitrile gloves, a lab coat, and safety goggles is required to prevent accidental exposure via inhalation or skin contact
• Administrative Controls: Maintain strict, detailed inventory logs. Access must be restricted to authorized, trained personnel only. Store in a locked, dedicated cabinet
• Waste Disposal: All waste materials must be deactivated and disposed of as hazardous chemical waste in compliance with all local, state, and federal regulations

5. Ordering & Packaging Information
Available to verified research institutions and qualified professionals:

• 250 mg (Small-Scale Research)
• 1 g (Standard Research Quantity)
• 5 g (Extended Research Program)
• Custom Quantities (For large-scale or long-term studies)

Every Order Includes:

• Certificate of Analysis (CoA): Detailed report with HPLC purity data and batch-specific information
• Material Safety Data Sheet (MSDS): Comprehensive safety and handling instructions
• Secure, Discreet Packaging: Tamper-evident, vacuum-sealed bags within anonymous outer packaging to ensure privacy and product integrity