Lidocaine Freebase (CAS 137-58-6)

Description

1. Comprehensive Chemical Overview
Lidocaine Freebase (CAS 137-58-6) represents the fundamental molecular form of one of the world’s most versatile local anesthetics, providing the chemical foundation for numerous pharmaceutical formulations. Unlike its water-soluble hydrochloride salt counterpart, Lidocaine freebase exhibits enhanced lipid solubility, making it particularly valuable for transdermal formulations and specialized delivery systems.

2. Elite Technical Specifications

• Chemical Name: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
• Synonyms: Lignocaine Base, Lidocaine Base
• CAS Number: 137-58-6
• Molecular Formula: C₁₄H₂₂N₂O
• Molecular Weight: 234.34 g/mol
• Appearance: White to off-white crystalline powder
• Purity: ≥99% (Pharmaceutical Grade, HPLC-verified)
• Solubility: Freely soluble in ethanol, acetone, and chloroform; sparingly soluble in water
• Melting Point: 66-69°C
• Storage: Store in airtight, light-resistant containers at controlled room temperature

3. Authorized Applications & Uses
1. Transdermal Delivery Systems

• Enhanced penetration formulations for topical anesthetics
• Patch technologies requiring lipid-soluble active ingredients
• Dermatological preparations with improved skin permeability
• Cosmetic applications requiring deep tissue penetration

2. Mucosal & Specialized Formulations

• Mucoadhesive delivery systems for oral and genital mucosa
• Liposomal encapsulation for sustained release formulations
• Oil-based preparations where water solubility is undesirable
• Veterinary formulations requiring enhanced tissue penetration

3. Pharmaceutical Research & Development

• Structure-activity relationship studies of local anesthetics
• Drug delivery optimization for enhanced bioavailability
• Alternative formulation development for patients with allergy to lidocaine hydrochloride
• Comparative studies of different salt forms and their pharmacokinetics

4. Pharmacological & Chemical Profile

• Mechanism of Action: Potent voltage-gated sodium channel blockade
• Prevents neuronal depolarization and action potential propagation
• Rapid penetration through lipid membranes
• Superior lipid solubility compared to the hydrochloride salt

5. Critical Safety & Handling Information
WARNING: Lidocaine Freebase is a potent pharmaceutical compound with cardiac and neurological effects at high doses. Proper handling and professional use are mandatory.

Safety Considerations:

• Lidocaine side effects may include CNS and cardiovascular toxicity
• Allergy to lidocaine is rare but possible; appropriate testing recommended
• Alternative to lidocaine may be required for sensitive patients
• Professional formulation required before any medical application

Handling Protocols:

• Use appropriate PPE: nitrile gloves, lab coat, and safety goggles
• Handle in controlled pharmaceutical environments only
• Implement engineering controls for powder handling
• Follow strict quality control measures for formulation work