Lidocaine Hydrochloride (CAS 73-78-9)

Description

1. Comprehensive Pharmaceutical Overview
Lidocaine Hydrochloride (CAS 73-78-9) represents the global gold standard in local anesthesia, serving as the active pharmaceutical ingredient in countless medical formulations worldwide. It is an amide-type local anesthetic that revolutionized pain management through its rapid onset, intermediate duration, and excellent safety profile. This lidocaine hydrochloride powder is manufactured to United States Pharmacopeia (USP) standards.

2. Elite Technical Specifications

• Chemical Name: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride
• Synonyms: Lignocaine Hydrochloride
• CAS Number: 73-78-9
• Molecular Formula: C₁₄H₂₂N₂O · HCl
• Molecular Weight: 270.80 g/mol
• Appearance: White, crystalline, hygroscopic powder
• Purity: ≥99% (USP Grade, HPLC-verified)
• Solubility: Freely soluble in water (1:1), soluble in ethanol (1:2)
• Melting Point: 75-78°C
• pH: 4.0–5.5 (1% aqueous solution)
• Storage: Store in airtight, light-resistant containers with desiccant at 15-30°C

3. Authorized Applications & Uses
1. Topical Anesthetic Formulations

• Lidocaine cream preparations (1%, 2%, 4%, 5% concentrations)
• Lidocaine gel for mucosal and surface anesthesia
• Lidocaine ointment USP 5% for dermatological use
• Topical lidocaine solutions for pre-procedural skin preparation

2. Injectable Anesthetics

• Lidocaine injection solutions for infiltration and nerve block
• Lidocaine HCl Injection USP in various concentrations (0.5%, 1%, 2%)
• Lidocaine ampoules for single-use medical procedures
• Regional anesthesia formulations for surgical use

3. Mucosal & Oral Preparations

• Viscous lidocaine solutions for oropharyngeal anesthesia
• Lidocaine oral solution for painful mouth conditions
• Lidocaine mouth rinse for dental procedures
• Lidocaine jelly for urological and endoscopic procedures

4. Specialized Medical Compounding

• Custom concentration lidocaine topical formulations
• Veterinary anesthetic preparations
• Combination products with other therapeutic agents

4. Clinical & Pharmacological Profile

• Mechanism of Action: Potent voltage-gated sodium channel blockade
• Prevents neuronal depolarization and action potential propagation
• Rapid onset (2–5 minutes) with duration of 1–2 hours

5. Critical Safety & Handling Information
WARNING: Lidocaine Hydrochloride is a potent pharmaceutical agent with cardiac and neurological effects at high doses. Proper handling and professional use are mandatory.

Safety Protocols:

• Use appropriate PPE: nitrile gloves, lab coat, and safety goggles
• Handle in controlled pharmaceutical environments only
• Implement engineering controls for powder handling
• Follow strict aseptic techniques for formulation work

Professional Use Only:

• Not for over-the-counter consumer use without proper formulation
• Requires medical supervision for injectable administration
• Lidocaine hydrochloride powder must be properly formulated before use
• Follow all applicable regulatory guidelines