Procaine Freebase (CAS 59-46-1)

Description

1. Comprehensive Chemical Overview
Procaine Freebase (CAS 59-46-1) represents the fundamental molecular form of one of medicine’s earliest synthetic local anesthetics. It is a para-aminobenzoic acid ester that serves as the active pharmaceutical ingredient precursor. This procaine powder in its freebase form offers superior solubility in organic solvents compared to its hydrochloride salt, making it particularly valuable for specific pharmaceutical manufacturing processes.

2. Elite Technical Specifications

• Chemical Name: 2-Diethylaminoethyl 4-aminobenzoate
• CAS Number: 59-46-1
• Molecular Formula: C₁₃H₂₀N₂O₂
• Molecular Weight: 236.31 g/mol
• Appearance: White crystalline powder
• Purity: ≥99% (HPLC-verified)
• Melting Point: 61°C
• Solubility: Highly soluble in ethanol, acetone, and chloroform; sparingly soluble in water
• Storage: Store in airtight container protected from light at 2-8°C

3. Authorized Applications & Uses
1. Pharmaceutical Manufacturing Intermediate

• Salt Formation: Primary material for synthesis of procaine hydrochloride (procaine HCl)
• Antibiotic Formulations: Key intermediate in production of procaine penicillin and procaine penicillin G
• Veterinary Medicine: Used in penicillin dose cattle preparations and other veterinary pharmaceutical products

2. Research & Development

• Comparative Studies: Research into mechanisms of local anesthesia (procaine vs lidocaine)
• Structure-Activity Relationships: Studies exploring the procaine formula and its relationship to anesthetic potency
• Allergy Research: Investigation of procaine allergy alternatives and hypersensitivity mechanisms

3. Compounding Pharmacy Applications

• Custom Formulations: Used by licensed compounding pharmacies for specialized preparations
• Therapeutic Innovations: Research into novel applications including procaine IV therapy protocols

4. Clinical & Pharmacological Profile

• Local anesthesia for dental and minor surgical procedures
• Component of procaine penicillin injection formulations for sustained antibiotic delivery
• Historical use in various pain management protocols
• Procaine has shorter duration and slower onset compared to lidocaine

5. Critical Safety & Handling Information
WARNING: Procaine Freebase is a pharmaceutical intermediate with bioactive properties. It is NOT for human or veterinary use in its raw form. This product is sold strictly for pharmaceutical research, development, and compounding applications.

Safety Data:

• Procaine drug classification: Local anesthetic (ester type)
• Potential for allergic reactions in sensitive individuals
• CNS and cardiovascular effects at elevated doses
• Proper handling requires appropriate PPE and ventilation

Handling Protocols:

• Use in controlled laboratory environments only
• Wear appropriate PPE: nitrile gloves, lab coat, and safety goggles
• Handle under fume hood when working with powders
• Store in secure, temperature-controlled conditions