Procaine Hydrochloride (CAS 51-05-8)

Description

1. Comprehensive Pharmaceutical Overview
Procaine Hydrochloride (CAS 51-05-8), historically and commonly known as Novocaine, represents one of the first synthetic local anesthetics and remains a fundamental compound in medical and dental practice. It is an ester-type local anesthetic that revolutionized pain management in clinical settings. This procaine HCl powder is provided in United States Pharmacopeia (USP) grade quality.

2. Elite Technical Specifications

• Chemical Name: 2-Diethylaminoethyl 4-aminobenzoate hydrochloride
• Synonyms: Novocaine, Procaine HCl
• CAS Number: 51-05-8
• Molecular Formula: C₁₃H₂₀N₂O₂ · HCl
• Molecular Weight: 272.77 g/mol
• Appearance: White, crystalline powder
• Purity: ≥99% (USP Grade, HPLC-verified)
• Solubility: Freely soluble in water (1:1), soluble in ethanol
• Melting Point: 156-158°C
• pH: 5.0–6.5 (1% aqueous solution)
• Storage: Store in airtight, light-resistant containers at controlled room temperature

3. Authorized Applications & Uses
1. Pharmaceutical Compounding & Manufacturing

• Dental Anesthesia: Primary ingredient in local anesthetic formulations for dental procedures
• Injectable Formulations: Used in procaine injections and procaine 2 injection products for minor surgical procedures
• Topical Preparations: Component of anesthetic creams and ointments for surface analgesia

2. Clinical Applications

• Infiltration Anesthesia: For minor surgical procedures and wound repair
• Nerve Block Anesthesia: For regional pain control in specific anatomical areas
• Therapeutic Injections: Used in some pain management protocols

3. Research & Development

• Comparative Studies: Research into mechanisms of local anesthesia and comparisons with newer agents
• Pharmacological Research: Studies of ester-based anesthetics and their metabolism
• Formulation Development: Development of novel delivery systems for local anesthetics

4. Clinical & Pharmacological Profile

• Mechanism of Action: Blocks voltage-gated sodium channels in neuronal membranes
• Prevents depolarization and propagation of action potentials
• Provides reversible loss of sensation in specific areas
• Onset: Rapid (5–10 minutes)
• Duration: Moderate (30–60 minutes)
• Metabolized by plasma esterases to para-aminobenzoic acid (PABA) and diethylaminoethanol

5. Critical Safety & Handling Information
WARNING: Procaine Hydrochloride is a potent pharmaceutical agent with specific clinical indications. It is NOT for consumer use. This product is sold strictly to qualified professionals for pharmaceutical compounding, research, and manufacturing applications.

Safety Data:

• Procaine drug classification: Local anesthetic (ester type)
• Potential for systemic effects if improperly administered
• Requires proper medical supervision for clinical use
• Potential for allergic reactions in sensitive individuals
• CNS and cardiovascular effects at excessive doses
• Contraindicated in patients with ester local anesthetic hypersensitivity

Handling Protocols:

• Use in controlled laboratory or pharmaceutical environments only
• Wear appropriate PPE: nitrile gloves, lab coat, and safety goggles
• Handle under appropriate ventilation when working with powders
• Store in secure, temperature-controlled conditions
• Follow aseptic techniques for pharmaceutical compounding