Tetramisole Hydrochloride, CAS 5086-74-8

Description

1. Comprehensive Chemical Overview
Tetramisole Hydrochloride (CAS 5086-74-8) represents a fundamental phenyltetrahydroimidazothiazole compound that serves as the racemic precursor to the widely used anthelmintic agent levamisole. This synthetic imidazothiazole derivative demonstrates significant biological activity against nematode parasites while providing researchers with a versatile intermediate for pharmaceutical development.

Our tetramisole hydrochloride API is manufactured to exacting pharmaceutical standards, offering a racemic mixture containing both dextro (levamisole) and levo isomers that can be separated for specific applications. The phenyltetrahydroimidazothiazole structure confers unique biochemical properties that make this compound invaluable for both direct anthelmintic use and as a critical intermediate in advanced pharmaceutical synthesis.

2. Elite Technical Specifications

• Chemical Name: (±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride
• IUPAC Classification: Phenyltetrahydroimidazothiazole derivative
• CAS Number: 5086-74-8
• Molecular Formula: C₁₁H₁₂N₂S · HCl
• Molecular Weight: 240.75 g/mol
• Appearance: White to off-white crystalline powder
• Purity: ≥98% (Pharmaceutical Grade, HPLC-verified)
• Solubility: Freely soluble in water, soluble in ethanol
• Melting Point: 265–267°C (with decomposition)
• Optical Activity: Racemic mixture (contains both levamisole and its enantiomer)
• Storage: Store in airtight, light-resistant containers at controlled room temperature

3. Authorized Applications & Uses
Our premium Tetramisole Hydrochloride serves critical roles in pharmaceutical manufacturing and research:

1. Pharmaceutical Intermediate

• Primary precursor for levamisole hydrochloride production
• Chiral separation studies for isomer isolation
• Synthetic intermediate for novel imidazothiazole derivatives
• Process development for anthelmintic manufacturing

2. Veterinary Anthelmintic Formulations

• Broad-spectrum deworming solutions for agricultural animals
• Racemic anthelmintic preparations where approved
• Poultry health products for nematode control
• Livestock medications for gastrointestinal parasite management

3. Research Applications

• Comparative studies of racemic vs enantiopure anthelmintics
• Metabolic pathway investigation of phenyltetrahydroimidazothiazoles
• Structure-activity relationship research for new parasitic control agents
• Analytical method development for imidazothiazole compounds

4. Pharmacological Profile
Understanding Phenyltetrahydroimidazothiazole Activity:

Chemical Relationship:

• Tetramisole serves as the racemic parent compound
• Levamisole represents the biologically active dextro enantiomer
• Both share the core phenyltetrahydroimidazothiazole structure
• Different therapeutic profiles based on isomeric composition

Mechanism of Action:

• Nicotinic acetylcholine receptor agonist at nematode neuromuscular junctions
• Causes spastic paralysis leading to parasite elimination
• A racemic mixture demonstrates broader receptor interactions
• Enantioselective metabolism and activity profiles

Research Significance:

• Comparative efficacy studies between racemic and enantiopure forms
• Metabolic profiling of imidazothiazole compounds
• Synthetic chemistry applications for chiral separation

5. Critical Safety & Handling Information
WARNING: TETRAMISOLE HYDROCHLORIDE IS A POTENT PHARMACEUTICAL COMPOUND REQUIRING PROFESSIONAL HANDLING. Proper safety protocols must be followed at all times.

Safety Protocols:

• Use appropriate PPE: nitrile gloves, lab coat, and safety goggles
• Handle in controlled pharmaceutical environments with adequate ventilation
• Implement engineering controls for powder handling operations
• Follow institutional guidelines for chemical safety and handling

Regulatory Compliance:

• For research and pharmaceutical manufacturing use only
• Not for direct animal or human administration without proper formulation
• Compliance with all relevant veterinary pharmaceutical regulations required
• Understanding of isomeric differences critical for proper application

6. Order Now – For Qualified Professionals Only
Secure Your Phenyltetrahydroimidazothiazole API
Advance your pharmaceutical research with our certified Tetramisole Hydrochloride.

PHARMACEUTICAL GRADE QUALITY:

• Batch-specific Certificate of Analysis
• HPLC purity verification ≥98%
• Comprehensive documentation package
• cGMP-compliant manufacturing standards
• Isomeric composition verification

Every Order Includes:

• Certificate of Analysis (CoA) with comprehensive testing data
• Material Safety Data Sheet (MSDS)
• Regulatory Compliance Documentation
• Technical Support Materials